BEATSEPSIS

NEWS

Outstanding BEATsepsis kickoff meeting in Brno celebrates the start of the project.

26.-28.03.2024

The BEATsep consortium unites eleven partners from six European countries. Top leaders of their field come together to bundle their efforts combating sepsis and its long-term consequences. The first kickoff was hosted by BEATsep coordinators from FNUSA, in Brno, Czechia. This was the first time all partners met together in person.

A warm Welcome in Brno

Brno did a formidable job as host. The hall in St Anne’s hospital was filled with researchers, both local and visiting, hospital staff, press, and the Who’s Who of Brno’s research landscape. The event started strong with welcome speeches by hosts Jan Frič and Marcela Hortová-Kohoutková, as well as Alessandra Martini, representing the Directorate General for Research & Innovation of the European Commission. An on-stage welcome panel demonstrated how big of a support BEATsepsis has in the Brno medical and research landscape. FNUSA Director Vlastimil Vajdák, Med MUNI Dean Martin Repko, ICRC Head of Clinic Irena Rektorová, FNUSA Deputy for Science and Research Vladimír Šrámek, and ICRC Director Michal Janota all dedicated time in their busy schedule to be present and make an active contribution to this great event.

Diverse expertise driving the BEATsepsis mission

After the formal welcome, the event program dived right into the subject of introducing the project. The consortium members introduced themselves and their unique contributions. The palette is as colorful as the picture we would like to paint (as artfully, in fact, that one talk also featured a spontaneous rendition of William Shakespeare’s Henry V). While some partners take a close look into the biomolecular intricacies of the human immune system, others approach sepsis from a hands-on clinical perspective or bring in the public health perspective to ensure the project has a concrete and meaningful effect on people’s lives. We are especially proud of this great diversity of expertise among our partners.

CzechTV was on location during the kickoff, filming and doing interviews with the Frič lab. The resulting news clip was watched by 360,000 within the first days after airing alone.

Heartfelt stories and community spirit

Dinner was preceded by short talks by clinicians, telling stories about the lives of patients surviving sepsis, reminding all of the participants of the cause they are working for together. Especially memorable was the story told by Lukáš Homola from the pediatric ICU at MedMUNI. Three girls, Christie, Maggie, and Natalie (names changed), were all treated for serious cases of sepsis. All three were cured and able to leave ICU. But while Christie and Natalie went on to live healthy lives, Maggie’s life was turned upside down by post-sepsis complications. Homola asks the question: How can we find Maggie? How can we predict post-sepsis complications? This is going to be a leading question of BEATsepsis: Who is Maggie? What makes her different?

What united the entire BEATsep kickoff meeting was a strong sense of community, united by the bond of a common cause. People just “clicked,” like puzzle pieces falling into place. Conny Schneider from LBI Trauma later recapped on Twitter: “The BEATsepsis kickoff was hands down the best scientific gathering I have been to and likely ever will.” In the name of the entire BEATsep consortium, we would like to highlight the people who made this possible: Jan Frič, Marcela Hortová-Kohoutková, Petra Kozlová. Thank you!

Prestigious grant HORIZON EUROPE - “BEATsep” will tackle long-term consequences of sepsis.

11.09.2023

The research consortium BEATsep, established by the Cellular and Molecular Immunoregulation (CMI) research team at the International Clinical Research Centre (ICRC), has been awarded a 6.9 million euro HORIZON EUROPE grant. The project entitled “Biomarkers established to stratify sepsis long-term adverse effects to improve patients’ health and quality of life (BEATsep)" aims to define markers of poor recovery of patients after sepsis and septic shock. This will be achieved through the discovery of novel mechanisms and their markers predicting the decline of health-related quality of life after sepsis. Sepsis and septic shock, affecting up to 50 million people worldwide with mortality reaching 20%, leaves large cohorts of vulnerable patients suffering from long-term complications that affect their quality of life.

The BEATsep project will apply an interdisciplinary approach bringing together research and clinical teams working on specific aspects of the development, treatment and prevention of the long-term consequences of sepsis and its impact on patients' quality of life. Comprehensive clinical and research data generated during the project will be integrated using artificial intelligence algorithms into an easy-to-use predictive tool capable of identifying patients at high risk of complications. Furthermore, the consortium plans to design a tertiary prevention strategy to improve the recovery outcomes.

For the next five years, the consortium brings six European countries together in a joint mission to understand and fight the long-term consequences of sepsis.

The consortium is coordinated by ICRC-FNUSA and will consist of leading European institutions including: 1) CIML - Centre d'immunologie de Marseille-Luminy – (Aix-Marseille Université/CNRS/Inserm); 2) The Institute of Innate Immunity, at the Medical Faculty of the University of Bonn, Germany; 3) Faculty of Medicine at the Comenius University in Slovakia; 4) the Ludwig Boltzmann Institute for Traumatology, Vienna, Austria; 5) BioVariance GmbH, Germany; 6) Masaryk University, Brno, Czechia; 7) National Institute of Health, Prague, Czechia; 8) University of Galway and 9) APHM - Marseille Hospitals. BEATsep assembles renowned experts in immuno-metabolism and epigenetics, immunophenotyping, diagnostic research and several clinical teams treating adult and pediatric sepsis patients. "It has taken nearly two years of intensive preparation and networking to assemble the consortium. We used the advantage of bringing together teams with whom we have been already collaborating on several other projects." says Dr. Marcela Hortová-Kohoutková from the CMI research group, who co-headed the project's preparation.

In total, 10 partners from renowned European research and clinical institutions and 1 commercial partner in six EU countries will be involved in the BEATsep. The project is an example of an innovative and successful combination of translational and clinical research, the know-how of several international scientists, and the collaboration between hospitals, universities and other scientific institutions.

For more information and updates: @BEATsepsis (X); LinkedIN

Presentation Day of Immunotherapy

16.05.2023

Ioanna Papatheodorou introduced BEATsep during the conference “Immunity and immunotherapy in current clinical practice.” This conference organized by Czech Immunology Society and Medical Faculty Pilzen, Charles University was a great event to discuss the current state of sepsis therapies and future perspectives, how to target sepsis and its long-lasting consequences. Ioanna Papatheodorou is a new member of ICRC team, greatly experienced in the field of immunometabolism and bioinformatics.

Presentation on yEFIS

26.04.2023

The BEATsep mission was successfully presented during the conference “Mixer 2023” of Czech Young Immunologist Society by Marcela Hortova-Kohoutkova as one of the Keynote lectures. This conference was held as an occasion during celebrations of the World Day of Immunology.

BEATsep won the prize of the best poster during Colours of Sepsis

27.01.2023

At the end of January 2023, the 25th edition of the international conference Colours of Sepsis dedicated to sepsis and intensive medicine in adults and children took place in Ostrava, and hosted many eminent international guests. BEATsep consortium was successfully represented at this conference by Dr. Marcela Hortová-Kohoutková and Dr. Jan Frič from Cellular and Molecular Immunoregulation team. Marcela presented a poster on the topic “Functional changes of monocytes and neutrophils as early markers of septic shock severity”, which won the main poster section of Colours of Sepsis. “Our projects have long focused on the study of sepsis and septic shock, where the immune system plays a crucial role in their development and subsequent course. We are looking at functional changes in cells of innate immunity, especially monocytes and neutrophils. We have been able to show that patients with a poor prognosis have strongly altered functions of innate immunity. We are able to detect these changes already at the time of admission to the intensive care unit. The early analysis could help in the future to select patients who do not respond to conventional treatment and are therefore candidates for personalized treatment.”

CONTACT

E-mail: info@beatsepsis.eu

FNUSA ICRC

Studentská 812/6, 625 00 Brno

Czech Republic

BeatSep Twitter BeatSep LinkedIn

Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Health and Digital Executive Agency (HADEA). Neither the European Union nor the granting authority can be held responsible for them.

Information of individuals and respect for „computer and freedom“ rights - General information about research activities in the institution must be provided to the persons concerned.

© 2023 Veronika Bosáková

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NEWS

Sepsis Awareness Month with BEATsepsis

This September, BEATsepsis joined global efforts to raise awareness about sepsis, a critical yet often misunderstood medical emergency. With activities across Europe, BEATsepsis bridged the gap between research and real-world action, engaging communities through workshops, talks, and campaigns to make sepsis awareness an essential part of public health. Here, we recap a month full of events that highlighted the urgent need for better recognition and rapid response to sepsis symptoms—steps that could ultimately save lives.

Sepsis research in action: BEATsepsis members connect in Brno

In celebration of World Sepsis Day, our coordinators from FricLab at St. Anne’s University Hospital in Brno hosted a working group meeting were BEATsepsis Consortium members came together for presentations and in depth discussion. The interdisciplinary group of researchers and healthcare professionals shared insights into their methods, discussed hot topics in sepsis research and dived into clinical aspects of the project. With the first patients already recruited, there is a spirit of action among all project members.

Educating Austria’s youth on sepsis recognition

In Austria, there are twice as many deaths from sepsis than from heart attack, yet while education on how to recognize and act upon a heart attack is widespread (and rightfully so!), the signs of sepsis are rarely taught in school. Conny Schneider from LBI Trauma is determined to change that by educating future generations. In a pioneering workshop, she guided 11th and 12th-grade students through sepsis case studies, helping them recognise symptoms and understand the necessary steps to address the condition. The workshop did not stop at theory—the students were invited to the lab, where they explored hands-on research methods, making complex scientific concepts more tangible.

Engaging communities at the European Night of Science

Awareness efforts also took center stage at the European Night of Science, where Michal Pastorek from the Institute of Molecular Biomedicine at the Faculty of Medicine in Bratislava delivered an inspiring talk on sepsis and the research happening at BEATsepsis partner institutions. Following the presentation, young attendees participated in interactive workshops that made learning about sepsis both accessible and fun to cultivate a new generation of sepsis-aware individuals.

Expert insights in media: Personalising sepsis care

Marcin Osuchowski from LBI Trauma also contributed to the month’s awareness efforts through insightful articles in widely-read media. In “When the immune system runs amok” in popular German magazine Spektrum der Wissenschaft, he discussed the science behind sepsis pathophysiology and called for personalised sepsis therapies. An article in RiffReporter opened with the moving story of sepsis survivor Craig Mackinlay, whose life was saved by timely recognition of his symptoms by those around him.

Busting myths and reaching new audiences

Throughout the month, Conny Schneider tackled widespread misconceptions about sepsis through a series of "Sepsis Myths" videos. These short clips addressed commonly held beliefs and myths about sepsis. Additionally, LBI Trauma participated in the Vienna Business Run, showcasing not only athletic team spirit but also raising awareness about sepsis among its 30.000 participants as part of World Sepsis Month.

The mission continues beyond September

Sepsis Awareness Month may be over, but our work is far from complete. As BEATsepsis moves forward, our mission remains clear: to raise awareness, support survivors, and push research that will one day make sepsis preventable and survivable for all. Join us as we continue our commitment to education, research, and advocacy—empowering individuals with the knowledge they need to make a life-saving difference.

Outstanding BEATsepsis kickoff meeting in Brno celebrates the start of the project. / 26.-28.03.2024

The BEATsep consortium unites eleven partners from six European countries. Top leaders of their field come together to bundle their efforts combating sepsis and its long-term consequences. The first kickoff was hosted by BEATsep coordinators from FNUSA, in Brno, Czechia. This was the first time all partners met together in person.

A warm Welcome in Brno

Brno did a formidable job as host. The hall in St Anne’s hospital was filled with researchers, both local and visiting, hospital staff, press, and the Who’s Who of Brno’s research landscape. The event started strong with welcome speeches by hosts Jan Frič and Marcela Hortová-Kohoutková, as well as Alessandra Martini, representing the Directorate General for Research & Innovation of the European Commission. An on-stage welcome panel demonstrated how big of a support BEATsepsis has in the Brno medical and research landscape. FNUSA Director Vlastimil Vajdák, Med MUNI Dean Martin Repko, ICRC Head of Clinic Irena Rektorová, FNUSA Deputy for Science and Research Vladimír Šrámek, and ICRC Director Michal Janota all dedicated time in their busy schedule to be present and make an active contribution to this great event.

Diverse expertise driving the BEATsepsis mission

After the formal welcome, the event program dived right into the subject of introducing the project. The consortium members introduced themselves and their unique contributions. The palette is as colorful as the picture we would like to paint (as artfully, in fact, that one talk also featured a spontaneous rendition of William Shakespeare’s Henry V). While some partners take a close look into the biomolecular intricacies of the human immune system, others approach sepsis from a hands-on clinical perspective or bring in the public health perspective to ensure the project has a concrete and meaningful effect on people’s lives. We are especially proud of this great diversity of expertise among our partners.

CzechTV was on location during the kickoff, filming and doing interviews with the Frič lab. The resulting news clip was watched by 360,000 within the first days after airing alone.

Heartfelt stories and community spirit

Dinner was preceded by short talks by clinicians, telling stories about the lives of patients surviving sepsis, reminding all of the participants of the cause they are working for together. Especially memorable was the story told by Lukáš Homola from the pediatric ICU at MedMUNI. Three girls, Christie, Maggie, and Natalie (names changed), were all treated for serious cases of sepsis. All three were cured and able to leave ICU. But while Christie and Natalie went on to live healthy lives, Maggie’s life was turned upside down by post-sepsis complications. Homola asks the question: How can we find Maggie? How can we predict post-sepsis complications? This is going to be a leading question of BEATsepsis: Who is Maggie? What makes her different?

What united the entire BEATsep kickoff meeting was a strong sense of community, united by the bond of a common cause. People just “clicked,” like puzzle pieces falling into place. Conny Schneider from LBI Trauma later recapped on Twitter: “The BEATsepsis kickoff was hands down the best scientific gathering I have been to and likely ever will.” In the name of the entire BEATsep consortium, we would like to highlight the people who made this possible: Jan Frič, Marcela Hortová-Kohoutková, Petra Kozlová. Thank you!

Prestigious grant HORIZON EUROPE - “BEATsep” will tackle long-term consequences of sepsis. / 11.09.2023

The research consortium BEATsep, established by the Cellular and Molecular Immunoregulation (CMI) research team at the International Clinical Research Centre (ICRC), has been awarded a 6.9 million euro HORIZON EUROPE grant. The project entitled “Biomarkers established to stratify sepsis long-term adverse effects to improve patients’ health and quality of life (BEATsep)" aims to define markers of poor recovery of patients after sepsis and septic shock. This will be achieved through the discovery of novel mechanisms and their markers predicting the decline of health-related quality of life after sepsis. Sepsis and septic shock, affecting up to 50 million people worldwide with mortality reaching 20%, leaves large cohorts of vulnerable patients suffering from long-term complications that affect their quality of life.

The BEATsep project will apply an interdisciplinary approach bringing together research and clinical teams working on specific aspects of the development, treatment and prevention of the long-term consequences of sepsis and its impact on patients' quality of life. Comprehensive clinical and research data generated during the project will be integrated using artificial intelligence algorithms into an easy-to-use predictive tool capable of identifying patients at high risk of complications. Furthermore, the consortium plans to design a tertiary prevention strategy to improve the recovery outcomes.

For the next five years, the consortium brings six European countries together in a joint mission to understand and fight the long-term consequences of sepsis.

The consortium is coordinated by ICRC-FNUSA and will consist of leading European institutions including: 1) CIML - Centre d'immunologie de Marseille-Luminy – (Aix-Marseille Université/CNRS/Inserm); 2) The Institute of Innate Immunity, at the Medical Faculty of the University of Bonn, Germany; 3) Faculty of Medicine at the Comenius University in Slovakia; 4) the Ludwig Boltzmann Institute for Traumatology, Vienna, Austria; 5) BioVariance GmbH, Germany; 6) Masaryk University, Brno, Czechia; 7) National Institute of Health, Prague, Czechia; 8) University of Galway and 9) APHM - Marseille Hospitals. BEATsep assembles renowned experts in immuno-metabolism and epigenetics, immunophenotyping, diagnostic research and several clinical teams treating adult and pediatric sepsis patients. "It has taken nearly two years of intensive preparation and networking to assemble the consortium. We used the advantage of bringing together teams with whom we have been already collaborating on several other projects." says Dr. Marcela Hortová-Kohoutková from the CMI research group, who co-headed the project's preparation.

In total, 10 partners from renowned European research and clinical institutions and 1 commercial partner in six EU countries will be involved in the BEATsep. The project is an example of an innovative and successful combination of translational and clinical research, the know-how of several international scientists, and the collaboration between hospitals, universities and other scientific institutions.

For more information and updates: @BEATsepsis (X); LinkedIN

day of immunotherapy

Presentation Day of Immunotherapy / 16.05.2023

Ioanna Papatheodorou introduced BEATsep during the conference “Immunity and immunotherapy in current clinical practice.” This conference organized by Czech Immunology Society and Medical Faculty Pilzen, Charles University was a great event to discuss the current state of sepsis therapies and future perspectives, how to target sepsis and its long-lasting consequences. Ioanna Papatheodorou is a new member of ICRC team, greatly experienced in the field of immunometabolism and bioinformatics.

Presentation on yEFIS / 26.04.2023

The BEATsep mission was successfully presented during the conference “Mixer 2023” of Czech Young Immunologist Society by Marcela Hortova-Kohoutkova as one of the Keynote lectures. This conference was held as an occasion during celebrations of the World Day of Immunology.

BEATsep yEFIS
BEATsep colours of sepsis

BEATsep won the prize of the best poster during Colours of Sepsis / 27.01.2023

At the end of January 2023, the 25th edition of the international conference Colours of Sepsis dedicated to sepsis and intensive medicine in adults and children took place in Ostrava, and hosted many eminent international guests. BEATsep consortium was successfully represented at this conference by Dr. Marcela Hortová-Kohoutková and Dr. Jan Frič from Cellular and Molecular Immunoregulation team. Marcela presented a poster on the topic “Functional changes of monocytes and neutrophils as early markers of septic shock severity”, which won the main poster section of Colours of Sepsis. “Our projects have long focused on the study of sepsis and septic shock, where the immune system plays a crucial role in their development and subsequent course. We are looking at functional changes in cells of innate immunity, especially monocytes and neutrophils. We have been able to show that patients with a poor prognosis have strongly altered functions of innate immunity. We are able to detect these changes already at the time of admission to the intensive care unit. The early analysis could help in the future to select patients who do not respond to conventional treatment and are therefore candidates for personalized treatment.”

Beatsepsis

BEATSEPSIS

E-mail: info@beatsepsis.eu

CONTACT

ICRC FNUSA

Studentská 812/6, 625 00 Brno

Czech Republic

FOLLOW US

Twitter

LinkedIn

Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Health and Digital Executive Agency (HADEA). Neither the European Union nor the granting authority can be held responsible for them.

Information of individuals and respect for „computer and freedom“ rights - General information about research activities in the institution must be provided to the persons concerned.

© 2023 Veronika Bosáková

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Ludwig Boltzman Institute (LBI)

Ludwig Boltzman Institute (LBI) is a top-tier specialised Austrian center for critical/intensive care medicine (ICM) research. LBI Trauma is consistently rated as excellent (2010, 2015, 2020) by international evaluators. The primary objective of the LBI Trauma is to improve diagnostic and therapeutic measures in trauma/infection care. LBI regularly organises top-tier international congresses (e.g., the Wiggers-Bernard Conference for Modelling of Sepsis, TERMIS for tissue engineering, and European Shock Society). LBI is involved in several ongoing Austrian and European research projects and has received numerous international and national grants (including 5-7th Framework and 2020 EU grants, EUROSTARS, FWF-GENAU, FFG-Bridge, FFG-Comet, WWTF, LBF, Wings for Life, Nationalbank, OEAW; http://trauma.lbg.ac.at/en/about-us). The institute is at the forefront of bench-to-bedside research and has experimentally developed several diagnostic and/or treatment approaches now routinely employed in clinics. LBI experts regularly coordinate/participate in various ICM task forces (e.g., the Task Force for Coagulation) and create guidelines in the area of pre- and clinical intensive care research (e.g., 2023 Management of Perioperative Bleeding; 2018 MQTiPSS; 2017 Goal-directed Coagulation Management). The institute features a robust multidisciplinary environment composed of different research groups working in the fields of sepsis, shock, trauma, tissue regeneration, molecular biology, and imaging.

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Universitätsklinikum Bonn (UKB) and Institute of Innate Immunity (III)

Universitätsklinikum Bonn (UKB) and Institute of Innate Immunity (III) are one of the best-evaluated medical centers in Europe. The UKB offers a diverse and rich research environment for immunology and has attracted numerous talented researchers from all over the world. This effort is reflected by the University’s status as an Excellence University in Germany and by the generous and continuous funding it receives from the Excellence Cluster ImmunoSensation. The Institute of Innate Immunity, which has renowned expertise in the field of innate immunity (https://www.iiibonn.de/) and inflammation, is equipped with cutting-edge instrumentation and facilities. Moreover, it is a hot spot for immunology in Europe, hosting groups working in areas such as structural biology and cellular immunology. The Institute of Innate Immunity is funded by grants from the European Research Council (ERC), and Germany’s Excellence Strategy (EXC 2151 – 390873048) from the DFG.

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Centre d'Immuologie Marseille-Lumily (CIML)

Centre d'Immuologie Marseille-Lumily (CIML) situated within Aix Marseille University's multidisciplinary campus, is a premier immunology research institute, comprising 17 research teams, seven cutting-edge technology platforms, and 17 prestigious ERC grants. Its strong track record in high-quality research, 50 patented inventions, and numerous collaborations with esteemed institutions and private foundations underscore its dynamism and global impact. Emphasizing both scientific and medical vocations, the CIML expedites diagnostic and therapeutic advancements for patients, and has launched successful biotech companies such as Innate Pharma and Ipsogen. Collaborations with renowned institutions like Harvard Medical School, EMBL, and UCSF, as well as engagement in projects like PIA, EUROBIOMED, and the Marseille-Immunopole federation, further illustrate the institute's unwavering dedication to excellence. The CIML's state-of-the-art technology platforms, encompassing cytometry (featuring three 5-laser spectral flow cytometers, including Europe's first spectral sorter), bioinformatics, functional genomics, and imaging, firmly establish its status as a leading research institution in immunology and related disciplines.

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Commenius University Bratislava (CU)

Commenius University Bratislava (CU) and Institute of Molecular Biomedicine (www.imbm.sk) is a research institute of the Faculty of Medicine at the Comenius University in Slovakia with the staff having a vast range of educational background – from molecular biology, biophysics, biotechnology or physiology, up to medicine. Institute is focused on the role of extracellular DNA (NETs) in variety pathologies including sepsis and has established several animal models that can be utilized in the research of systemic inflammation and its consequences. We believe that interdisciplinarity is a key scientific value and our partnerships extend to collaborating with clinicians in Slovakia and complementary research institutes all around the globe. IMBM will together with University Hospitals in Bratislava provide patient samples as well as the analysis of NETs.

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Masaryk University Brno (MUNI)

Masaryk University Brno (MUNI) team consists from several departments included in BEATsep i) Department of Paediatric Infection Diseases, ii) Department of Paediatric Anaesthesiology and Intensive Care Medicine and iii) CEITEC Multimodal and Functional Imaging Laboratory (MAFIL) is one of the core facilities at the Central European Institute of Technology (CEITEC), Masaryk University. MAFIL is part of the national research infrastructure Czech-BioImaging as well as the European infrastructure Euro-BioImaging and provides access for a wide research community in the field of neuroimaging, brain mapping, and other magnetic resonance imaging applications. MAFIL has been involved in various international projects and consortia (including JPND projects, COST projects, Czech-Austrian bilateral projects, and H2020 RISE) and has provided services for more than 100 research projects with several thousands of MRI or EEG measurements since 2015. Both clinical teams are associated with Faculty Hospital Brno (FNB) which is a collaborating organisation of the project and an important patient sample provider.

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National University of Ireland (NUI)

National University of Ireland (NUI) and the Lung Biology Cluster who will be conducting this research have interests in sepsis, lung injury, cell and gene therapies. NUI has received funding from the ERC, Health Research Board, Science Foundation Ireland and Irish Research Council as well as co-funded projects with industry partners in nebulisation, stem cell therapy and sepsis topics. NUI have an interest in development and application of novel technologies for organ support and therapeutic drug delivery in the critically ill and in the application of data analytic approaches to this population, with experience in ICU patient sample biobanking and flow cytometry and serum soluble factor quantification. NUI have initiated and become affiliated sites in a number of clinical trials for ARDS and sepsis and now for COVID-19. NUI have developed drugs from cell cultures testing, to preclinical animal models for first in man trials.

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Assistance Publique-Hopitaux de Marseille (APHM)

Assistance Publique-Hopitaux de Marseille (APHM) represents top-tier French hospital with four emergency departments admitting around 109 intensive care unit (ICU) beds admitting around 5000 patients/year. For the proposed work, two adult ICUs (25 beds) and one paediatric ICU (15 beds) will be involved, representing yearly around 1800 adult patients and 100 adult patients with septic shock. The APHM team is focused on the biology of sepsis and septic shock documented by many high-impact factor publications.

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BIOVARIANCE

BIOVARIANCE comprises pharma-experienced, professional management and a multidisciplinary team of specialists, which combines experience and expertise across technology, innovation, and the life science industry. BEATsep will directly benefit from the expertise of BioVariance, a SME with great experience in the development of comprehensive predictive models for the diagnosis of various diseases (e.g., colorectal cancer) or psychological consequences (such as depression). Moreover, BioVariance will prepare a simplified predictive tool to stratify patients based on their risk of developing PICS. This model could take the form of a risk score assigned to patients based on their immune-related marker profile and other relevant clinical factors.

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National Institute of Health (SZU, “Státní zdravotní ústav”))

National Institute of Health (SZU, “Státní zdravotní ústav”)) Czech National Health Institute, works on health care establishment for preventive disciplines such as vaccinology, health promotion, nutrition, environmental sciences and for other topics of public health, with disease prevention and health promotion among the major tasks of institute. SZU concentrates the most important health problems including as epidemiological surveillance of severe infections. Our promotion of a healthy life styles and nutrition and in prevention of cardiovascular diseases, cancer, addictions. The Institute has experience in solving and participating in international projects, especially in EU funded projects such as European joint actions (JAHEE, JAMRAI, JATC2 and others).